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The heart is extremely vulnerable to CO poisoning as heart muscle binds three times more avidly to CO than skeletal muscle. Also, due to formation of COHb, ischemia is also a resultant effect on cardiac function.This may result in arrhythmias and conduction defects.
The main injury to the brain in addition to the effects of general lack of oxygen is damage to the basal ganglia, resulting in Parkinson-like syndrome. Delayed effects may include movement disorders, memory disturbances, personality changes, psychosis, dementia, reduced IQ, cortical blindness and deafness. Back to Top
The main tissue poisons are:
The main causes of CO poisoning include:
The half-life of CO is diminished significantly with administration of HBOT. Adjunctive therapy should include reducing cerebral edema with steroids and Mannitol.Cellular protection with magnesium treatment consists of oxygen at 1.3 atmospheres for hours until COHb is less than 10% in acute poisoning. In chronic or delayed poisoning, treatment usually consists of multiple sessions. Normobaric oxygen should not be used between multiple hyperbaric oxygen treatments, as this may contribute to oxygen toxicity. Delayed treatment is utilized to awaken the “idling neurones”, and to induce cerebral reparative processes. What is critical to understand that if firefighters are showing even minor neurological findings after a “smoke-inhalation” episode, a trial of HBOT is warranted. Back to Top