Parkinson's Disease

Overview

This disease, of uncertain origin, usually affects people over the age of 60, however, it may affect younger people when causative factors are present:

  • Post-encephalitis
  • Post brain injury (acute or chronic repetitive such as boxing)
  • Carbon monoxide poisoning
  • Heavy metal toxicity
  • Certain drugs
  • Juvenile Idiopathic Parkinson's

About 1% of the US population is affected and males more than females have this disease. Peculiarly, smokers are less affected than the general population. The predominant symptom is a tremor that increases with time. Mental impairment is usually not a feature. There may be mood changes and depression as the disease progresses.

Possible Causes of Parkinson's Disease:

  • Chemicals - environmental chemicals, exposure to drugs, and industrial solvents Pesticides/Herbicides - the two common substances implicated are paraquat (pesticide) and maneb (fungicide)
  • Individuals with Familial Parkinson's disease have a much lower level of detoxifying enzymes (30% of normal values)
  • Metals
    • Aluminum - allows other toxic metals to cross the blood-brain barrier. Aluminum also has neurotoxin properties such as: inhibits synthesis of important brain chemicals, blocks nucleic acid, synthesis within nerve cells, and interferes with magnesium in regeneration of neuro-transmitter receptors. Source are; food additives, some baking powders, cooking utensils, buffered aspirin, antacids, deodorants, tobacco smoke, ceramics, aluminum soda cans, nasal sprays, aerosol sprays, astringents, automobile exhaust, and municipal water supply. Target organs are C.N.S., kidneys, and digestive system.
    • Mercury - brain deterioration may occur due to accumulation of cadmium, lead and mercury. If one has two or more different metals in the mouth, they may induce micro-currents that interfere with nerve function.
    • Iron - overload can intensify Parkinson's as well as it tends to catalyst free-radical reactions that destroy dopamine-reducing cells. Sources include; accidental/inadvertent ingestion of iron, drinking water, iron-plumbing pipes and cookware. The target organs are liver, kidneys and C.V.S.
    • Copper - cerebrospinal levels are higher in Parkinson's Disease. Also found to be higher in autoimmune/chronic inflammatory/undetected allergic reactions when copper levels are high, in the presence of, anti-oxidant deficiency resultant increased free-radical damage to nerve cell DNA occurs.
    • Endotoxins - toxins released by dead bacteria that occurs due to overgrowth of small intestinal bacteria/fungi. Aspirin may cause allergic inflammation of intestinal wall, allowing partly digested foods and bacterial endotoxins to be absorbed. When these substances reach the brain they act as neurotoxins. In a "sensitive" brain, they may produce psychotic symptoms. Another common cause is a root canal. This may cause a multitude of problems especially if has an associated heavy metal cap inserted as well.
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Symptoms

These are attributed to loss of brain cells in the Basal Ganglia which produce dopamine. There appears to be decreased availability of other neurotransmitters such as Serotonin and Norepinephrine. The symptoms also tend to worsen when patient is tired, excited or frustrated.

  • Early on there is a tremor when at rest but during attempted various functional movements the shaking stops
  • In progression, "pill rolling" of fingers occurs
  • The face assumes a mask-like appearance
  • Increased "stiffness" and muscles become weak and rigid
  • Walking becomes slow with a "shuffle"
  • Everyday activities such as eating, bathing, and dressing becomes increasingly more difficult and unmanageable

One may get a Parkinson-like syndrome from:

  • Certain tranquilizers/antihypertensives
  • MTP (designer drug)
  • Iron/Aluminum
  • Reserpine
  • Haloperidol
  • Some Phenothiazines
  • Dopamine-blockers/depleting drugs
  • Alpha-methyl dopa
  • Calcium-channel blockers
  • Carbon monoxide poisoning
  • Brain arteriosclerosis
  • Stroke
  • Head injury
  • Syphilis
  • Malaria/polio
  • Post-encephalitis
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Management

Conventional Management for Parkinson's Disease

  • L-Dopa
  • Dopamine-sparing drugs
  • Dyskinesia is a common side-effect, but less so than with L-dopa. After 5 years of continuous L-Dopa management, motor fluctuations and abnormal involuntary movements commonly begin to develop. May also get neurotic and psychotic symptoms - this is due to the accumulation of oxidation of L-Dopa and Dopamine breakdown products, managed with High doses of Niacin/Niacinamide and Vitamin C.
  • Adrenal Grafts - highly controversial. May give rise to severe psychotic and neurotic symptoms. Occurs die to accumulation of Adrenochrome, an oxidation product of Norepinephrine.
  • Theophilline - this is a non-selective adenosine-receptor-antagonist, so adenosine accumulates, which is both a neurotransmitter and it inhibits the release of Dopamine from the central synaptic terminals.

Natural Managements for Parkinson's Disease

  • CoQ10 - this protects neurons against excitotoxicity from being exposed to L-glutamate. Excitotoxicity, if severe enough, may lead to neuronal death. CoQ10 also helps mitochondrial function improve.
  • Amino acids
  • Antioxidants
  • Specific Vitamins
  • Grape seed extract
  • Bioflavonoids
  • Melatonin
  • Vitamins/supplements/hormones
  • Avoid sugar, saturated and trans-fatty acids, and refined carbohydrates. Avoid high protein diet that decreases absorption of essential amino-acids, so less L-Dopa is made. Fish is recommended - haddock, sardines, flounder, wild pacific salmon. (Safe mercury-free fish: www.ewg.org)
  • Good Protein Drink: Spoonful of wheat-barley grass, spirulina, chlorella, several spoons of bee pollen. Blend with fresh vegetable juice (low-sodium) or with blackcurrant juice. (Drink coffee 20 minutes before for best results)
  • Intravenous management

Overall, Dr. Allibone is a specialist at finding the root of the cause in each individual patient and creating a management plan tailored to those findings. This method is used to achieve the best long-term results for optimal health.

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Learn more about how the Houston Wellness Clinic manages Parkinson's Disease.

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If we fill our hours with regrets of yesterday and with worries of tomorrow, we have no today in which to enjoy our existence. Seize the day, and take control of your health and life. How you are going to live those tomorrows will depend on how you act and choose today. - George Allibone M.D.