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Pesticides exposure, both occupational and in-home, has been associated with Parkinsonism in numerous studies. There is a strong association with organo-chlorines and alkylated phosphates. There has been noted that PD may occur secondary to exposure to other toxins. These include mercury, manganese, lead, copper and iron. Carbon monoxide and carbon tetrachloride poisonings can be etiological agents.
A number of underlying mechanisms occur during HBOT. It may act as an anti-inflammatory, or in cases where an underlying infection such as mycoplasma or Lyme disease is present, as an anti-infective agent. HBOT helps to eradicate the infection with the help of other treatments such as antibiotics, homeopathics, and herbal medications. In a recently published large study of 64 patients where HBOT treatments were utilized, 55 of the cases showed significant improvement. The most favorable outcomes were seen in vascular Parkinson's Disease with the akinetico-rigid syndrome regressing more than the trembling hyperkinetic syndrome. A second study found HBOT so effective that the need for medication, such as Sinemet was obviated.
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